Structure and antiinflammatory activity relationships of wogonin derivatives.

نویسندگان

  • Jinhee Jang
  • Kwan-Seog Sin
  • Hyun Pyo Kim
  • Haeil Park
چکیده

A number of wogonin derivatives have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE2 production. Wogonin derivatives modified at the B ring of wogonin were obtained from 2,4-Dihydroxy-3,6-dimethoxyacetophenone (1) via several steps. Most wogonin derivatives exhibited much reduced inhibitory activities against COX-2 catalyzed PGE2 production compared to that of wogonin. Alkylation of 5,7-phenol groups and substitution at the B ring of wogonin generally caused reduction of inhibitory activity.

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عنوان ژورنال:
  • Archives of pharmacal research

دوره 28 8  شماره 

صفحات  -

تاریخ انتشار 2005